High circulating elafin levels are associated with Crohn's disease-associated intestinal strictures.

ABSTRACT:

Background

Antimicrobial peptide expression is associated with disease activity in inflammatory bowel disease (IBD) patients. IBD patients have abnormal expression of elafin, a human elastase-specific protease inhibitor and antimicrobial peptide. We determined elafin expression in blood, intestine, and mesenteric fat of IBD and non-IBD patients.

Methods

Serum samples from normal and IBD patients were collected from two UCLA cohorts. Surgical resection samples of human colonic and mesenteric fat tissues from IBD and non-IBD (colon cancer) patients were collected from Cedars-Sinai Medical Center.

Results

High serum elafin levels were associated with a significantly elevated risk of intestinal stricture in Crohn's disease (CD) patients. Microsoft Azure Machine learning a

SUBMITTER: Wang J 

PROVIDER: S-EPMC7156098 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature