Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family.

ABSTRACT: Microorganisms have evolved specific cell surface molecules that enable discrimination between cells from the same and from a different kind. Here, we investigate the role of Flo11-type cell surface adhesins from social yeasts in kin discrimination. We measure the adhesion forces mediated by Flo11A-type domains using single-cell force spectroscopy, quantify Flo11A-based cell aggregation in populations and determine the Flo11A-dependent segregation of competing yeast strains in biofilms. We find that Flo11A domains from diverse yeast species confer remarkably strong adhesion forces by establishing homotypic interactions between single cells, leading to efficient cell aggregation and biofilm formation in homogenous populations. Heterotypic interactions between Flo11A domains from different y

SUBMITTER: Bruckner S 

PROVIDER: S-EPMC7156268 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature