Clinical Evaluation of Cingulum Bundle Connectivity for Neurosurgical Hypothesis Development.

ABSTRACT:

Background

The cingulum bundle (CB) has long been a target for psychiatric neurosurgical procedures, but with limited understanding of the brain networks being impacted. Recent advances in human tractography could provide a foundation to better understand the effects of neurosurgical interventions on the CB; however, the reliability of tractography remains in question.

Objective

To evaluate the ability of different tractography techniques, derived from typical, human diffusion-weighted imaging (DWI) data, to characterize CB connectivity described in animal models. This will help validate the clinical applicability of tractography, and generate insight on current and future neurosurgical targets for psychiatric disorders.

Methods

Connectivity of the CB in 15 healthy hu

SUBMITTER: Sweet JA 

PROVIDER: S-EPMC7156292 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature