Electrolyte and transporter responses to angiotensin II induced hypertension in female and male rats and mice.

ABSTRACT:

Aim

Sexual dimorphisms are evident along the nephron: Females (F) exhibit higher ratios of renal distal to proximal Na⁺ transporters' abundance, greater lithium clearance (C_Li ) more rapid natriuresis in response to saline infusion and lower plasma [K⁺ ] vs. males (M). During angiotensin II infusion hypertension (AngII-HTN) M exhibit distal Na⁺ transporter activation, lower proximal and medullary loop transporters, blunted natriuresis in response to saline load, and reduced plasma [K⁺ ]. This study aimed to determine whether responses of F to AngII-HTN mimicked those in M or were impacted by sexual dimorphisms evident at baseline.

Methods

Sprague Dawley rats and C57BL/6 mice were AngII infused via osmotic minipumps 2 and

SUBMITTER: Veiras LC 

PROVIDER: S-EPMC7156336 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature