Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype.

ABSTRACT: Retinoid metabolites of vitamin A are intrinsically linked to neural development, connectivity and plasticity, and have been implicated in the pathophysiology of schizophrenia. We hypothesised that a greater burden of common and rare genomic variation in genes involved with retinoid biogenesis and signalling could be associated with schizophrenia and its cognitive symptoms. Common variants associated with schizophrenia in the largest genome-wide association study were aggregated in retinoid genes and used to formulate a polygenic risk score (PRS_Ret) for each participant in the Australian Schizophrenia Research Bank. In support of our hypothesis, we found PRS_Ret to be significantly associated with the disorder. Cases with severe cognitive deficits, while not further di

SUBMITTER: Reay WR 

PROVIDER: S-EPMC7156344 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature