Genetic heterogeneity and evolutionary history of high-grade ovarian carcinoma and matched distant metastases.

ABSTRACT:

Background

High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian carcinoma, associated with poor clinical outcome and metastatic disease. Although metastatic processes are becoming more understandable, the genomic landscape and metastatic progression in HGSOC has not been elucidated.

Methods

Multi-region whole-exome sequencing was performed on HGSOC primary tumours and their metastases (n = 33 tumour regions) from six patients. The resulting somatic variants were analysed to delineate tumour evolution and metastatic dissemination, and to compare the repertoire of events between primary HGSOC and metastasis.

Results

All cases presented branching evolution patterns in primary HGSOC, with three cases further showing parallel evolution in which

SUBMITTER: Masoodi T 

PROVIDER: S-EPMC7156387 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature