The establishment of neuron-specific enolase reference interval for the healthy population in southwest China.

ABSTRACT: To investigate and establish a reference interval (RI) of neuron-specific enolase (NSE) in southwest China's healthy population by using the laboratory information system database. A total of 86957 periodic health examination individuals of the medical examination center in West China Hospital from 2016 to 2018 were included in the study. We used the Box-Cox conversion combined with the Tukey method to normalize the data and eliminate the outliers, and the normal distribution method and the nonparametric method to estimate the 95% distribution RI. The NSE 95% distribution RI we established in healthy populations in southwest China through normal distribution and nonparametric method were 0-19.64?ng/ml and 0-20.46?ng/ml, respectively. The obtained RIs verification conformed to the standard and was significantly different from the reagent instruction(P?

SUBMITTER: Miao Q 

PROVIDER: S-EPMC7156405 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature