Systemic and pulmonary C1q as biomarker of progressive disease in experimental non-human primate tuberculosis.

ABSTRACT: Tuberculosis (TB) causes 1.6 million deaths annually. Early differential diagnosis of active TB infection is essential in optimizing treatment and reducing TB mortality, but is hampered by a lack of accurate and accessible diagnostics. Previously, we reported on complement component C1q, measured in serum by ELISA, as a candidate biomarker for active tuberculosis. In this work we further examine the dynamics of C1q as a marker of progressive TB disease in non-human primates (NHP). We assessed systemic and pulmonary C1q levels after experimental infection using high or low single dose as well as repeated limiting dose Mycobacterium tuberculosis (Mtb) challenge of macaques. We show that increasing C1q levels, either peripherally or locally, correlate with progressive TB disease, assessed by

SUBMITTER: Dijkman K 

PROVIDER: S-EPMC7156429 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature