Simultaneous Measurement of Perfusion and T₂* in Calf Muscle at 7T with Submaximal Exercise using Radial Acquisition.

ABSTRACT: Impairments in oxygen delivery and consumption can lead to reduced muscle endurance and physical disability. Perfusion, a measure of microvascular blood flow, provides information on nutrient delivery. T₂* provides information about relative tissue oxygenation. Changes in these parameters following stress, such as exercise, can yield important information about imbalance between delivery and consumption. In this study, we implemented novel golden angle radial MRI acquisition technique to simultaneously quantify muscle perfusion and T₂* at 7T with improved temporal resolution, and demonstrated assessment of spatial and temporal changes in these parameters within calf muscles during recovery from plantar flexion exercise. Nine healthy subjects participated the studies.

SUBMITTER: Mahmud SZ 

PROVIDER: S-EPMC7156440 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature