Glycogen metabolism regulates macrophage-mediated acute inflammatory responses.

ABSTRACT: Our current understanding of how sugar metabolism affects inflammatory pathways in macrophages is incomplete. Here, we show that glycogen metabolism is an important event that controls macrophage-mediated inflammatory responses. IFN-γ/LPS treatment stimulates macrophages to synthesize glycogen, which is then channeled through glycogenolysis to generate G6P and further through the pentose phosphate pathway to yield abundant NADPH, ensuring high levels of reduced glutathione for inflammatory macrophage survival. Meanwhile, glycogen metabolism also increases UDPG levels and the receptor P2Y₁₄ in macrophages. The UDPG/P2Y₁₄ signaling pathway not only upregulates the expression of STAT1 via activating RARβ but also promotes STAT1 phosphorylation by downregulating phosphata

SUBMITTER: Ma J 

PROVIDER: S-EPMC7156451 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature