Up-regulation of pro-angiogenic pathways and induction of neovascularization by an acute retinal light damage.

ABSTRACT: The light damage (LD) model was mainly used to study some of the main aspects of age related macular degeneration (AMD), such as oxidative stress and photoreceptor death. Several protocols of light-induced retinal degeneration exist. Acute light damage is characterized by a brief exposure (24 hours) to high intensity light (1000 lux) and leads to focal degeneration of the retina which progresses over time. To date there are not experimental data that relate this model to neovascular events. Therefore, the purpose of this study was to characterize the retina after an acute light damage to assess whether the vascularization was affected. Functional, molecular and morphological investigations were carried out. The electroretinographic response was assessed at all recovery times (7, 60, 120 da

SUBMITTER: Tisi A 

PROVIDER: S-EPMC7156521 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature