Blue Light Deprivation Produces Depression-Like Responses in Mongolian Gerbils.

ABSTRACT:

Background

Depression is a leading cause of disability worldwide and is a major contributor to the overall global burden of disease, but its etiology is poorly understood. It has been reported that a disrupted biological rhythm, in terms of a shortened light duration and total darkness, can cause depression-like behaviors in animals. Blue light was reported to have an inhibitory effect on melatonin, which is considered an important clock rhythm biomarker. In the present study, we investigated the effects of blue light deprivation on depressive-like behaviors in gerbils and explored the underlying mechanisms.

Methods

Gerbils were housed under white light with a filter to block the blue light or without a filter. The behaviors of the gerbils were observed. The biological rhyth

SUBMITTER: Hu H 

PROVIDER: S-EPMC7156555 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature