Non-motor Symptoms in Chinese Patients With Isolated Generalized Dystonia: A Case-Control Study.

ABSTRACT: Background: Previous studies have indicated that non-motor symptoms are primary problems in focal dystonia, but limited data are available about non-motor problems and their correlation with motor severity in generalized dystonia (GD). Methods: In the present study, we performed a case-control study and enrolled isolated inherited or idiopathic GD patients and age- and sex-matched healthy controls (HC). Clinical characteristics, motor symptoms, non-motor problems, including psychiatric co-morbidity, sleep problems, fatigue, and quality of life (QoL) were assessed in both groups using various rating scales and assessments. Results: Thirty-three patients with GD and 33 controls were enrolled. Significant higher scores on depression and anxiety (p < 0.001) were sho

SUBMITTER: Li S 

PROVIDER: S-EPMC7156613 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature