Delayed application of silver nanoparticles reveals the role of early inflammation in burn wound healing.

ABSTRACT: Burn injury is common, and antimicrobial agents are often applied immediately to prevent wound infection and excessive inflammatory response. Although inflammation is essential for clearing bacteria and creating an environment conducive to the healing process, it is unclear what time-frame inflammation should be present for optimal wound healing. This study critically investigated the role of early inflammation in burn wound healing, and also revealed the molecular mechanisms underlying the pro-healing effects of silver nanoparticles (AgNPs). We created a burn injury mouse model using wild-type and Smad3-/- mice, which were topically treated with AgNPs at different post-burn days, and examined the healing processes of the various groups. We also delineated the molecular pathways underlying

SUBMITTER: Zhang K 

PROVIDER: S-EPMC7156632 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature