Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.

ABSTRACT: Mutations that inactivate negative translation regulators cause autism spectrum disorders (ASD), which predominantly affect males and exhibit social interaction and communication deficits and repetitive behaviors. However, the cells that cause ASD through elevated protein synthesis resulting from these mutations remain unknown. Here we employ conditional overexpression of translation initiation factor eIF4E to increase protein synthesis in specific brain cells. We show that exaggerated translation in microglia, but not neurons or astrocytes, leads to autism-like behaviors in male mice. Although microglial eIF4E overexpression elevates translation in both sexes, it only increases microglial density and size in males, accompanied by microglial shift from homeostatic to a functional state wit

SUBMITTER: Xu ZX 

PROVIDER: S-EPMC7156673 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature