Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation.

ABSTRACT: Although group 3 innate lymphoid cells (ILC3s) are efficient inducers of T cell responses in the spleen, they fail to induce CD4⁺ T cell proliferation in the gut. The signals regulating ILC3-T cell responses remain unknown. Here, we show that transcripts associated with MHC II antigen presentation are down-modulated in intestinal natural cytotoxicity receptor (NCR)^- ILC3s. Further data implicate microbiota-induced IL-23 as a crucial signal for reversible silencing of MHC II in ILC3s, thereby reducing the capacity of ILC3s to present antigen to T cells in the intestinal mucosa. Moreover, IL-23-mediated MHC II suppression is dependent on mTORC1 and STAT3 phosphorylation in NCR^- ILC3s. By contrast, splenic interferon-γ induces MHC II expression and CD4^+</

SUBMITTER: Lehmann FM 

PROVIDER: S-EPMC7156681 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature