Case-control study of paternal occupational exposures and childhood bone tumours and soft-tissue sarcomas in Great Britain, 1962-2010.

ABSTRACT:

Background

This nationwide study investigated associations between paternal occupational exposure and childhood bone tumours and soft- tissue sarcomas.

Methods

The UK National Registry of Childhood Tumours provided cases of childhood sarcomas born and diagnosed in Great Britain, 1962-2010. Control births, unaffected by childhood cancer, were matched on sex, birth period and birth registration sub-district. Fathers' occupations were assigned to one or more of 33 exposure groups and coded for occupational social class.

Results

We analysed 5,369 childhood sarcoma cases and 5380 controls. Total bone tumours, total soft-tissue sarcomas and the subgroups osteosarcoma, rhabdomyosarcoma and Ewing Sarcoma Family of Tumours (ESFT) were considered separately. Significant positiv

SUBMITTER: Kendall GM 

PROVIDER: S-EPMC7156690 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature