Ontology highlight
ABSTRACT:
SUBMITTER: Holmes ZE
PROVIDER: S-EPMC7156710 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nature communications 20200414 1
Certain transcription factors are proposed to form functional interactions with RNA to facilitate proper regulation of gene expression. Sox2, a transcription factor critical for maintenance of pluripotency and neurogenesis, has been found associated with several lncRNAs, although it is unknown whether these interactions are direct or via other proteins. Here we demonstrate that human Sox2 interacts directly with one of these lncRNAs with high affinity through its HMG DNA-binding domain in vitro. ...[more]