Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington's Disease.

ABSTRACT:

Background

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded CAG repeat in the HTT gene. It is diagnosed following a standardized examination of motor control and often presents with cognitive decline and psychiatric symptoms. Recent studies have detected genetic loci modifying the age at onset of motor symptoms in HD, but genetic factors influencing cognitive and psychiatric presentations are unknown.

Methods

We tested the hypothesis that psychiatric and cognitive symptoms in HD are influenced by the same common genetic variation as in the general population by 1) constructing polygenic risk scores from large genome-wide association studies of psychiatric and neurodegenerative disorders and of intelligence and 2) testing for correlat

SUBMITTER: Ellis N 

PROVIDER: S-EPMC7156911 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature