Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trial.
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ABSTRACT:
SUBMITTER: Pantaleo G
PROVIDER: S-EPMC7156919 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trial.
Pantaleo Giuseppe G Janes Holly H Karuna Shelly S Grant Shannon S Ouedraogo G Laissa GL Allen Mary M Tomaras Georgia D GD Frahm Nicole N Montefiori David C DC Ferrari Guido G Ding Song S Lee Carter C Robb Merlin L ML Esteban Mariano M Wagner Ralf R Bart Pierre-Alexandre PA Rettby Nils N McElrath M Juliana MJ Gilbert Peter B PB Kublin James G JG Corey Lawrence L
The lancet. HIV 20191007 11
<h4>Background</h4>Up to now, immunisation regimens that have been assessed for development of HIV vaccines have included purified envelope (Env) protein among the boosting components of the regimen. We postulated that co-administration of Env protein with either a DNA or NYVAC vector during priming would result in early generation of antibody responses to the Env V1/V2 region, which are important markers for effective protection against infection. We aimed to assess the safety and immunogenicit ...[more]
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