The Association of Abdominal Adiposity With Mortality in Patients With Stage I-III Colorectal Cancer.

ABSTRACT:

Background

The quantity and distribution of adipose tissue may be prognostic measures of mortality in colorectal cancer patients, and such associations may vary by patient sex.

Methods

This cohort included 3262 stage I-III colorectal cancer patients. Visceral and subcutaneous adipose tissues were quantified using computed tomography. The primary endpoint was all-cause mortality. Restricted cubic splines estimated statistical associations with two-sided P values.

Results

Visceral adipose tissue was prognostic of mortality in a reverse L-shaped pattern (nonlinear P = .02); risk was flat to a threshold (∼260 cm2) then increased linearly. Subcutaneous adipose tissue was prognostic of mortality in a J-shaped pattern (nonlinear P < .001); risk was higher at extreme (<50 cm2

SUBMITTER: Brown JC 

PROVIDER: S-EPMC7156926 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature