Mammographic Density Change and Risk of Breast Cancer.

ABSTRACT:

Background

We examined the association between annual mammographic density change (MDC) and breast cancer (BC) risk, and how annual MDC influences the association between baseline mammographic density (MD) and BC risk.

Methods

We used the Karolinska Mammography Project for Risk Prediction of Breast Cancer cohort of Swedish women (N = 43 810) aged 30-79 years with full access to BC risk factors and mammograms. MD was measured as dense area (cm2) and percent MD using the STRATUS method. We used the contralateral mammogram for women with BC and randomly selected a mammogram from either left or right breast for healthy women. We calculated relative area MDC between repeated examinations. Relative area MDC was categorized as decreased (>10% decrease per year), stable (no change),

SUBMITTER: Azam S 

PROVIDER: S-EPMC7156933 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature