Ontology highlight
ABSTRACT:
SUBMITTER: Maffei B
PROVIDER: S-EPMC7156965 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Maffei Benoit B Laverrière Marc M Wu Yongzheng Y Triboulet Sébastien S Perrinet Stéphanie S Duchateau Magalie M Matondo Mariette M Hollis Robert L RL Gourley Charlie C Rupp Jan J Keillor Jeffrey W JW Subtil Agathe A
The EMBO journal 20200305 8
Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme with transamidating activity. We report here that both expression and activity of TG2 are enhanced in mammalian epithelial cells infected with the obligate intracellular bacteria Chlamydia trachomatis. Genetic or pharmacological inhibition of TG2 impairs bacterial development. We show that TG2 increases glucose import by up-regulating the transcription of the glucose transporter genes GLUT-1 and GLUT-3. Furthermore, TG2 activation drive ...[more]