Causality Assessment Guidelines for Adverse Events Following Immunization with a Focus on Guillain-Barre Syndrome.

ABSTRACT: South Korea operates a National Vaccine Injury Compensation Program (VICP) for people who experience adverse events following immunization (AEFI). To run this program rationally, it is a prerequisite to confirm whether adverse events were caused by immunization. Guillain-Barré syndrome (GBS), a severe neurological disease with limb pain and muscle weakness as cardinal symptoms, is attracting attention as an AEFI. However, algorithm or guidelines for assessing the causality between vaccination and the incidence of GBS are lacking. We aimed to develop guidelines for causality assessment of GBS as an AEFI and suggest using these guidelines in alignment with the VICP. We systematically searched for other previously published algorithms or guidelines and found a WHO-AEFI guideline used worldwid

SUBMITTER: Lee H 

PROVIDER: S-EPMC7157213 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature