Protein-Mediated and RNA-Based Origins of Replication of Extrachromosomal Mycobacterial Prophages.

ABSTRACT: Temperate bacteriophages are common and establish lysogens of their bacterial hosts in which the prophage is stably inherited. It is typical for such prophages to be integrated into the bacterial chromosome, but extrachromosomally replicating prophages have been described also, with the best characterized being the Escherichia coli phage P1 system. Among the large collection of sequenced mycobacteriophages, more than half are temperate or predicted to be temperate, most of which code for a tyrosine or serine integrase that promotes site-specific prophage integration. However, within the large group of 621 cluster A temperate phages, ∼20% lack an integration cassette, which is replaced with a parABS partitioning system. A subset of these phages carry genes coding for a RepA-li

SUBMITTER: Wetzel KS 

PROVIDER: S-EPMC7157519 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature