Avian Pattern Recognition Receptor Sensing and Signaling.

ABSTRACT: Pattern recognition receptors (PRRs) are a class of immune sensors that play a critical role in detecting and responding to several conserved patterns of microorganisms. As such, they play a major role in the maintenance of immune homeostasis and anti-microbial defense. Fundamental knowledge pertaining to the discovery of PRR functions and their ligands continue to advance the understanding of immune system and disease resistance, which led to the rational design and/or application of various PRR ligands as vaccine adjuvants. In addition, the conserved nature of many PRRs throughout the animal kingdom has enabled the utilization of the comparative genomics approach in PRR identification and the study of evolution, structural features, and functions in many animal species including avian. I

SUBMITTER: Neerukonda SN 

PROVIDER: S-EPMC7157566 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature