Design of an Epitope-Based Vaccine Ensemble for Animal Trypanosomiasis by Computational Methods.

ABSTRACT: African animal trypanosomiasis is caused by vector-transmitted parasites of the genus Trypanosoma. T. congolense and T. brucei brucei are predominant in Africa; T. evansi and T. vivax in America and Asia. They have in common an extracellular lifestyle and livestock tropism, which provokes huge economic losses in regions where vectors are endemic. There are licensed drugs to treat the infections, but adherence to treatment is poor and appearance of resistances common. Therefore, the availability of a prophylactic vaccine would represent a major breakthrough towards the management and control of the disease. Selection of the most appropriate antigens for its development is a bottleneck step, especially considering the limited resources allocated. Herein we

SUBMITTER: Michel-Todo L 

PROVIDER: S-EPMC7157688 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature