Identification and application of piwi-interacting RNAs from seminal plasma exosomes in Cynoglossus semilaevis.

ABSTRACT:

Background

Piwi-interacting RNAs (piRNAs) have been linked to epigenetic and post-transcriptional gene silencing of retrotransposons in germ line cells, particularly in spermatogenesis. Exosomes are important mediators of vesicle transport, and the piRNAs in exosomes might play an important role in cell communication and signal pathway regulation. Moreover, exosomic piRNAs are promising biomarkers for disease diagnosis and physiological status indication. We used Cynoglossus semilaevis because of its commercial value and its sexual dimorphism, particularly the sex reversed "pseudomales" who have a female karyotype, produce sperm, and copulate with normal females to produce viable offspring.

Results

To determine whether piRNAs from fish germ line cells have similar features,

SUBMITTER: Zhang B 

PROVIDER: S-EPMC7158113 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature