Adenosine kinase inhibition promotes proliferation of neural stem cells after traumatic brain injury.

ABSTRACT: Traumatic brain injury (TBI) is a major public health concern and remains a leading cause of disability and socio-economic burden. To date, there is no proven therapy that promotes brain repair following an injury to the brain. In this study, we explored the role of an isoform of adenosine kinase expressed in the cell nucleus (ADK-L) as a potential regulator of neural stem cell proliferation in the brain. The rationale for this hypothesis is based on coordinated expression changes of ADK-L during foetal and postnatal murine and human brain development indicating a role in the regulation of cell proliferation and plasticity in the brain. We first tested whether the genetic disruption of ADK-L would increase neural stem cell proliferation after TBI. Three days after TBI, modelled by a contro

SUBMITTER: Gebril HM 

PROVIDER: S-EPMC7158236 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature