RNA Sensing of Mycobacterium tuberculosis and Its Impact on TB Vaccination Strategies.

ABSTRACT: Tuberculosis (TB) is still an important global threat and although the causing organism has been discovered long ago, effective prevention strategies are lacking. Mycobacterium tuberculosis (MTB) is a unique pathogen with a complex host interaction. Understanding the immune responses upon infection with MTB is crucial for the development of new vaccination strategies and therapeutic targets for TB. Recently, it has been proposed that sensing bacterial nucleic acid in antigen-presenting cells via intracellular pattern recognition receptors (PRRs) is a central mechanism for initiating an effective host immune response. Here, we summarize key findings of the impact of mycobacterial RNA sensing for innate and adaptive host immunity after MTB infection, with emphasis on endosomal toll-like rece

SUBMITTER: Burkert S 

PROVIDER: S-EPMC7158685 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature