Self-administration of edible Δ⁹-tetrahydrocannabinol and associated behavioral effects in mice.

ABSTRACT:

Background

With increasing access to legal cannabis across the globe, it is imperative to more closely study its behavioral and physiological effects. Furthermore, with the proliferation of cannabis use, modes of consumption are changing, with edible formulations becoming increasingly popular. Nevertheless, there are relatively few animal models of self-administration of the primary psychoactive component of cannabis, Δ⁹-tetrahydrocannabinol (THC), and almost all incorporate routes of administration other than those used by humans. The aim of the current study was to develop a model of edible THC self-administration and assess its impact on CB1 receptor-mediated behaviors in female and male mice.

Methods

Mice were given limited access to a palatable dough which oc

SUBMITTER: Smoker MP 

PROVIDER: S-EPMC7158699 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature