Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma.

ABSTRACT: Glioblastoma (GB) is the most common and devastating form of brain cancer. Despite conventional treatments, progression or recurrences are systematic. In recent years, immunotherapies have emerged as an effective treatment in a number of cancers, leaving the question of their usefulness also faced with the particular case of brain tumors. The challenge here is major not only because the brain is the seat of our consciousness but also because of its isolation by the blood-brain barrier and the presence of a unique microenvironment that constitutes the central nervous system (CNS) with very specific constituent or patrolling cells. Much of the microenvironment is made up of immune cells or inflammation. Among these, tumor-associated macrophages (TAMs) are of significant interest as they are

SUBMITTER: Gregoire H 

PROVIDER: S-EPMC7158850 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature