Interleukin-1 alpha gene polymorphism (IL-1α) and susceptibility to tinnitus in the elderly.

ABSTRACT:

Aim

To investigate the association between the single nucleotide polymorphism in the position-889 (C/T) of the promoter region of the IL-1α gene and the susceptibility to tinnitus.

Method

This was a case-control study with a sample of 108 independent elderly people over 60 years of age. Information on exposure to occupational noise and tinnitus was obtained by interviews. The genetic polymorphism was analyzed by polymerase chain reaction followed by cleavage with restriction enzyme NcoI. Data were analyzed using the Chi-square test, with the significance level set at 5%. For the statistical analysis all individuals with tinnitus on the right ear were eligible.

Results

Among elderly with tinnitus, 42.9% had a history of exposure to occupational noise. There was statist

SUBMITTER: Marchiori LLM 

PROVIDER: S-EPMC7158897 | biostudies-literature | 2019 Mar-Apr

REPOSITORIES: biostudies-literature