Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission.

ABSTRACT: Influenza viruses cause seasonal outbreaks and pose a continuous pandemic threat. Although vaccines are available for influenza control, their efficacy varies each season and a vaccine for a novel pandemic virus manufactured using current technology will not be available fast enough to mitigate the effect of the first pandemic wave. Antivirals can be effective against many different influenza viruses but have not thus far been used extensively for outbreak control. Baloxavir, a recently licensed antiviral drug that targets the influenza virus endonuclease, has been shown to reduce virus shedding more effectively than oseltamivir, a widely used neuraminidase inhibitor drug. Thus it is possible that treatment with baloxavir might also interrupt onward virus transmission. To test this, we uti

SUBMITTER: Lee LYY 

PROVIDER: S-EPMC7159184 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature