Dysregulated biodynamics in metabolic attractor systems precede the emergence of amyotrophic lateral sclerosis.

ABSTRACT: Evolutionarily conserved mechanisms maintain homeostasis of essential elements, and are believed to be highly time-variant. However, current approaches measure elemental biomarkers at a few discrete time-points, ignoring complex higher-order dynamical features. To study dynamical properties of elemental homeostasis, we apply laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS) to tooth samples to generate 500 temporally sequential measurements of elemental concentrations from birth to 10 years. We applied dynamical system and Information Theory-based analyses to reveal the longest-known attractor system in mammalian biology underlying the metabolism of nutrient elements, and identify distinct and consistent transitions between stable and unstable states throughout develo

SUBMITTER: Curtin P 

PROVIDER: S-EPMC7159190 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature