Co-transmission of Related Malaria Parasite Lineages Shapes Within-Host Parasite Diversity.

ABSTRACT: In high-transmission regions, we expect parasite lineages within complex malaria infections to be unrelated due to parasite inoculations from different mosquitoes. This project was designed to test this prediction. We generated 485 single-cell genome sequences from fifteen P. falciparum malaria patients from Chikhwawa, Malawi-an area of intense transmission. Patients harbored up to seventeen unique parasite lineages. Surprisingly, parasite lineages within infections tend to be closely related, suggesting that superinfection by repeated mosquito bites is rarer than co-transmission of parasites from a single mosquito. Both closely and distantly related parasites comprise an infection, suggesting sequential transmission of complex infections between multiple hosts. We identified tetrads and r

SUBMITTER: Nkhoma SC 

PROVIDER: S-EPMC7159252 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature