Ontology highlight
ABSTRACT:
SUBMITTER: Jiang Z
PROVIDER: S-EPMC7159342 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Jiang Ziqing Z Gera Lajos L Mant Colin T CT Hirsch Brooke B Yan Zhe Z Shortt Jonathan A JA Shortt Jonathan A JA Pollock David D DD Qian Zhaohui Z Holmes Kathryn V KV Hodges Robert S RS
Biopolymers 20160301 2
We have utilized a de novo designed two-stranded α-helical coiled-coil template to display conserved α-helical epitopes from the stem region of hemagglutinin (HA) glycoproteins of influenza A. The immunogens have all the surface-exposed residues of the native α-helix in the native HA protein of interest displayed on the surface of the two-stranded α-helical coiled-coil template. This template when used as an immunogen elicits polyclonal antibodies which bind to the α-helix in the native protein. ...[more]