Impact of norepinephrine on right ventricular afterload and function in septic shock-a strain echocardiography study.

ABSTRACT:

Background

In this observational study, the effects of norepinephrine-induced changes in mean arterial pressure (MAP) on right ventricular (RV) systolic function, afterload and pulmonary haemodynamics were studied in septic shock patients. We hypothesised that RV systolic function improves at higher doses of norepinephrine/MAP levels.

Methods

Eleven patients with septic shock requiring norepinephrine after fluid resuscitation were included <24 hours after ICU arrival. Study enrolment and insertion of a pulmonary artery catheter was performed after written informed consent from the next of kin. Norepinephrine infusion was titrated to target mean arterial pressures (MAP) of 60, 75 and 90 mmHg in a random sequential order. At each target MAP, strain-and conventional echocardiog

SUBMITTER: Dalla K 

PROVIDER: S-EPMC7159388 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature