Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline.

ABSTRACT: Background: The diagnosis of sarcoidosis is not standardized but is based on three major criteria: a compatible clinical presentation, finding nonnecrotizing granulomatous inflammation in one or more tissue samples, and the exclusion of alternative causes of granulomatous disease. There are no universally accepted measures to determine if each diagnostic criterion has been satisfied; therefore, the diagnosis of sarcoidosis is never fully secure.Methods: Systematic reviews and, when appropriate, meta-analyses were performed to summarize the best available evidence. The evidence was appraised using the Grading of Recommendations, Assessment, Development, and Evaluation approach and then discussed by a multidisciplinary panel. Recommendations for or against various diagnostic te

SUBMITTER: Crouser ED 

PROVIDER: S-EPMC7159433 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature