Proliferating Infantile Hemangioma Tissues and Primary Cell Lines Express Markers Associated with Endothelial-to-Mesenchymal Transition.

ABSTRACT:

Background

We have previously shown that the endothelium of the microvessels of infantile hemangioma (IH) exhibits a hemogenic endothelium phenotype and proposed its potential to give rise to mesenchymal stem cells, similar to the development of hematopoietic cells. This endothelial-to-mesenchymal transition (Endo-MT) process involves the acquisition of a migratory phenotype by the endothelial cells, similar to epithelial-to-mesenchymal transition that occurs during neural crest development. We hypothesized that proliferating IH expresses Endo-MT-associated proteins and investigated their expression at the mRNA, protein, and functional levels.

Methods

Immunohistochemical staining of paraffin-embedded sections of proliferating IH samples from 10 patients was undertaken to inv

SUBMITTER: Itinteang T 

PROVIDER: S-EPMC7159972 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature