In vivo imaging of hemodynamic redistribution and arteriogenesis across microvascular network.

ABSTRACT:

Objective

Arteriogenesis is an important mechanism that contributes to restoration of oxygen supply in chronically ischemic tissues, but remains incompletely understood due to technical limitations. This study presents a novel approach for comprehensive assessment of the remodeling pattern in a complex microvascular network containing multiple collateral microvessels.

Methods

We have developed a hardware-software integrated platform for quantitative, longitudinal, and label-free imaging of network-wide hemodynamic changes and arteriogenesis at the single-vessel level. By ligating feeding arteries in the mouse ear, we induced network-wide hemodynamic redistribution and localized arteriogenesis. The utility of this technology was demonstrated by studying the influence of obesi

SUBMITTER: Sun N 

PROVIDER: S-EPMC7160018 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature