Systematic review and meta-analysis: efficacy and safety of early biologic treatment in adult and paediatric patients with Crohn's disease.

ABSTRACT:

Background

There is an increasing body of evidence showing that earlier use of biologics improves clinical outcomes in Crohn's disease (CD).

Aim

To perform a systematic review and meta-analysis to assess the impact of early biologic use in the treatment of CD.

Methods

PubMed and Embase databases were searched for English language papers and conference abstracts published through April 30, 2019. Studies were selected for inclusion if patients initiated biologics within 2 years of a CD diagnosis or if earlier biologics use (top-down) was compared with a conventional step-up strategy. Random-effects meta-analyses were conducted to compare clinical remission (CR), relapse and endoscopic healing rates between early biologic treatment (<2 years of disease duration or top-do

SUBMITTER: Ungaro RC 

PROVIDER: S-EPMC7160034 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature