Preoperative 18F-FDG PET/CT tumor markers outperform MRI-based markers for the prediction of lymph node metastases in primary endometrial cancer.

ABSTRACT:

Objectives

To compare the diagnostic accuracy of preoperative 18F-FDG PET/CT and MRI tumor markers for prediction of lymph node metastases (LNM) and aggressive disease in endometrial cancer (EC).

Methods

Preoperative whole-body 18F-FDG PET/CT and pelvic MRI were performed in 215 consecutive patients with histologically confirmed EC. PET/CT-based tumor standardized uptake value (SUV_max and SUV_mean), metabolic tumor volume (MTV), and PET-positive lymph nodes (LNs) (SUV_max > 2.5) were analyzed together with the MRI-based tumor volume (V_MRI), mean apparent diffusion coefficient (ADC_mean), and MRI-positive LN (maximum short-axis diameter ≥ 10 mm). Imaging parameters were explored in relation to surgicopathological stage and t

SUBMITTER: Fasmer KE 

PROVIDER: S-EPMC7160067 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature