Abnormal intrinsic functional hubs and connectivity in stable patients with COPD: a resting-state MRI study.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) affects a large population and is closely associated with cognitive impairment. However, the mechanisms of cognitive impairment in COPD patients have not been unraveled. This study investigated the change in patterns of intrinsic functional hubs using a degree centrality (DC) analysis. The connectivity between these abnormal hubs with the remaining brain was also investigated using functional connectivity (FC). Nineteen stable patients with COPD and 20 normal controls(NC) underwent functional magnetic resonance imaging (MRI) examinations and clinical and neuropsychologic assessments. We measured the voxel-wise DC across the whole brain gray matter and the seed-based FC between these abnormal hubs in the remaining brain matter; the group differen

SUBMITTER: Li H 

PROVIDER: S-EPMC7160072 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature