Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob mice.

ABSTRACT: It is crucial that the host and intestinal microflora interact and influence each other to maintain homeostasis and trigger pathological processes. Recent studies have shown that transplantation of the murine intestinal content to recipient germ-free mice enables transmission of the donor's phenotypes, such as low level chronic inflammation associated with lifestyle-related diseases. These findings indicate that intestinal bacteria produce some molecules to trigger pathological signals. However, fecal microbial metabolites that induce obesity and the type II diabetic phenotype have not been fully clarified. Here, we showed that the intestinal bacterial metabolite stercobilin, a pigment of feces, induced proinflammatory activities including TNF-α and IL-1β induction in mouse macrophage RAW2

SUBMITTER: Sanada S 

PROVIDER: S-EPMC7160104 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature