Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study.

ABSTRACT: Hypertension is an independent and preventable risk factor for the development of cardiovascular diseases, however, little is known about the impact of gut microbiota composition in its development. We carried out comprehensive gut microbiota analysis and targeted metabolomics in a cross-sectional study of 29 non-treated hypertensive (HT) and 32 normotensive (NT) subjects. We determined fecal microbiota composition by 16S rRNA gene sequencing and bacterial functions by metagenomic analysis. The microbial metabolites analysed were short chain fatty acids (SCFA) both in plasma and feces, and trimethylamine N-oxide (TMAO) in plasma. The overall bacterial composition and diversity of bacterial community in the two groups were not significantly different. However, Ruminococcaceae NK4A214, Rumin

SUBMITTER: Calderon-Perez L 

PROVIDER: S-EPMC7160119 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature