Subtype-Guided ¹⁸ F-FDG PET/CT in Tailoring Axillary Surgery Among Patients with Node-Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: A Feasibility Study.

ABSTRACT:

Background

The purpose of this study was to investigate the value of ¹⁸ [F]-fluorodeoxyglucose (¹⁸ F-FDG) positron emission tomography/computed tomography (PET/CT) in tailoring axillary surgery by predicting nodal response among patients with node-positive breast cancer after neoadjuvant chemotherapy (NAC).

Methods

One hundred thirty-three patients with breast cancer with biopsy-confirmed nodal metastasis were prospectively enrolled. ¹⁸ F-FDG PET/CT scan was performed before NAC (a second one after two cycles with baseline maximum standardized uptake value [SUV_max ] ≥2.5), and a subset of patients underwent targeted axillary dissection (TAD). All the patients underwent axillary lymph node dissection (ALND). The accuracy was calcula

SUBMITTER: Wu S 

PROVIDER: S-EPMC7160406 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature