Outcomes of second-line antiretroviral therapy among children living with HIV: a global cohort analysis.

ABSTRACT:

Introduction

Limited data describe outcomes on second-line antiretroviral therapy (ART) among children globally. Our objective was to contribute data on outcomes among children living with HIV after initiation of second-line ART in the context of routine care within a large global cohort collaboration.

Methods

Patient-level data from 1993 through 2015 from 11 paediatric HIV cohorts were pooled. Characteristics at switch and through two years of follow-up were summarized for children who switched to second-line ART after starting a standard first-line regimen in North America, Latin America, Europe, Asia, Southern Africa (South Africa & Botswana) and the rest of sub-Saharan Africa (SSA). Cumulative incidences of mortality and loss to follow-up (LTFU) were estimated using a co

SUBMITTER: Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration 

PROVIDER: S-EPMC7160415 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature