Serum retinol-binding protein 4 as a predictor of cardiovascular events in elderly patients with chronic heart failure.

ABSTRACT:

Aims

RBP4 is an adipokine with adverse effects on cardiovascular system. Increased circulating retinol-binding protein 4 (RBP4) has been linked to chronic heart failure (CHF). However, whether elevated RBP4 is correlated with a poor prognosis in elderly patients with CHF remains unclear. The aim of this study was to evaluate the prognostic value of serum RBP4 in elderly patients with CHF.

Methods and results

We enrolled 934 consecutive elderly patients (aged 60 years and older) with CHF and 138 age-matched and sex-matched control subjects in a prospective cohort study and explored the association of serum RBP4 levels with the clinical outcomes using multivariate Cox regression analyses. Serum RBP4 levels were elevated in CHF patients when compared with controls (46.66 ± 12.3

SUBMITTER: Li XZ 

PROVIDER: S-EPMC7160478 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature