Low fibre intake is associated with gut microbiota alterations in chronic heart failure.

ABSTRACT:

Aims

Recent reports have suggested that patients with heart failure (HF) have an altered gut microbiota composition; however, associations with diet remain largely uninvestigated. We aimed to explore differences in the gut microbiota between patients with HF with reduced ejection fraction and healthy controls, focusing on associations with diet and disease severity.

Methods and results

The microbiota composition of two cross-sectional cohorts (discovery, n = 40 and validation, n = 44) of patients with systolic HF and healthy controls (n = 266) was characterized by sequencing of the bacterial 16S rRNA gene. The overall microbial community (beta diversity) differed between patients with HF and healthy controls in both cohorts (P < 0.05). Patients with HF had shifts in the majo

SUBMITTER: Mayerhofer CCK 

PROVIDER: S-EPMC7160496 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature